Fri Jun 10 2022

73 articles - From Friday Jun 03 2022 to Friday Jun 10 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Ann Intern Med

Annals Video Summary - Cannabis-Based Products for Chronic Pain: A Systematic Review.

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Cannabinoids for Chronic Pain: Translating Systematic Review Findings Into Clinical Action.

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Cannabis-Based Products for Chronic Pain : A Systematic Review.

Oral, synthetic cannabis products with high THC-to-CBD ratios and sublingual, extracted cannabis products with comparable THC-to-CBD ratios may be associated with short-term improvements in chronic pain and increased risk for dizziness and sedation. Studies are needed on long-term outcomes and further evaluation of product formulation effects. Primary funding source Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services. (PROSPERO CRD42021229579).

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Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

Adults with first-time nephrotic syndrome had increased risk for thromboembolic events, higher near time of diagnosis.

2022; 135:615-25. e9. 34979093.

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Effect of Molnupiravir on Biomarkers, Respiratory Interventions, and Medical Services in COVID-19 : A Randomized, Placebo-Controlled Trial.

The findings suggest there are additional important clinical benefits of molnupiravir beyond reduction in hospitalization or death. Primary funding source Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc.

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In acute stroke with a large ischemic region, endovascular therapy improved functional status at 90 d.

Source citation Yoshimura S, Sakai N, Yamagami H, et al N Engl J Med. 2022; 386:1303-13. 35138767.

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In Black and Latinx patients, as-needed inhaled glucocorticoids reduced asthma exacerbations at 15 mo.

Source citation Israel E, Cardet JC, Carroll JK, et al N Engl J Med. 2022; 386:1505-18. 35213105.

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In HF with mitral regurgitation, adding transcatheter mitral valve repair to medical therapy improved renal outcomes at 2 y.

Source citation Beohar N, Ailawadi G, Kotinkaduwa LN, et al Eur Heart J. 2022; 43:1639-48. 35134897.

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In knee OA, PT vs. glucocorticoid injections had an incremental cost-effectiveness ratio of $35 527/QALY gained.

Source citation Rhon DI, Kim M, Asche CV, et al JAMA Netw Open. 2022; 5:e2142709. 35072722.

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In nonischemic systolic HF, prophylactic ICDs did not reduce all-cause mortality vs. usual care at 10 y.

Source citation Yafasova A, Butt JH, Elming MB, et al Circulation. 2022; 145:427-36. 34882430.

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In patients with COVID-19 at risk for severe disease, nirmatrelvir + ritonavir reduced hospitalization or death.

Source citation Hammond J, Leister-Tebbe H, Gardner A, et al N Engl J Med. 2022; 386:1397-408. 35172054.

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In patients with COVID-19 receiving IMV or ECMO, adding baricitinib to usual care reduced all-cause mortality.

Source citation Ely EW, Ramanan AV, Kartman CE, et al Lancet Respir Med. 2022; 10:327-36. 35123660.

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Patients surviving COVID-19 had increased risk for adverse mental health outcomes vs. persons without COVID-19.

BMJ. 2022; 376:e068993. 35172971.

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USPSTF found insufficient evidence on the benefits and harms of screening adults =50 y for AF.

Source citation Davidson KW, Barry MJ, Mangione CM, et al JAMA. 2022; 327:360-7. 35076659.

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Lancet

Intrauterine device-related uterine perforation incidence and risk (APEX-IUD): a large multisite cohort study.

Therefore, IUD insertion timing should be based on individual desire for IUD contraception and patient convenience to assure an IUD insertion can occur. Careful follow-up of individuals at higher risk of uterine perforation is warranted. Funding Bayer AG.

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N Engl J Med

Adagrasib in Non-Small-Cell Lung Cancer Harboring a KRASG12C Mutation.

Methods In a registrational phase 2 cohort, we evaluated adagrasib (600 mg orally twice daily) in patients with -mutated NSCLC, adagrasib showed clinical efficacy without new safety signals. (Funded by Mirati Therapeutics; ClinicalTrials. gov number, NCT03785249.).

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Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer.

A ctDNA-guided approach to the treatment of stage II colon cancer reduced adjuvant chemotherapy use without compromising recurrence-free survival. (Supported by the Australian National Health and Medical Research Council and others; DYNAMIC Australian New Zealand Clinical Trials Registry number, ACTRN12615000381583.).

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Ibrutinib plus Bendamustine and Rituximab in Untreated Mantle-Cell Lymphoma.

Ibrutinib treatment in combination with standard chemoimmunotherapy significantly prolonged progression-free survival. The safety profile of the combined therapy was consistent with the known profiles of the individual drugs. (Funded by Janssen Research and Development and Pharmacyclics; SHINE ClinicalTrials.gov number, NCT01776840.).

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Once-Weekly Dulaglutide for the Treatment of Youths with Type 2 Diabetes.

Treatment with dulaglutide at a once-weekly dose of 0.75 mg or 1.5 mg was superior to placebo in improving glycemic control through 26 weeks among youths with type 2 diabetes who were being treated with or without metformin or basal insulin, without an effect on BMI. (Funded by Eli Lilly; AWARD-PEDS ClinicalTrials.gov number, NCT02963766.).

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PD-1 Blockade in Mismatch Repair-Deficient, Locally Advanced Rectal Cancer.

Mismatch repair-deficient, locally advanced rectal cancer was highly sensitive to single-agent PD-1 blockade. Longer follow-up is needed to assess the duration of response. (Funded by the Simon and Eve Colin Foundation and others; ClinicalTrials.gov number, NCT04165772.).

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Teclistamab in Relapsed or Refractory Multiple Myeloma.

Teclistamab resulted in a high rate of deep and durable response in patients with triple-class-exposed relapsed or refractory multiple myeloma. Cytopenias and infections were common; toxic effects that were consistent with T-cell redirection were mostly grade 1 or 2. (Funded by Janssen Research and Development; MajesTEC-1 ClinicalTrials.gov numbers, NCT03145181 and NCT04557098.).

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Tirzepatide Once Weekly for the Treatment of Obesity.

In this 72-week trial in participants with obesity, 5 mg, 10 mg, or 15 mg of tirzepatide once weekly provided substantial and sustained reductions in body weight. (Supported by Eli Lilly; SURMOUNT-1 ClinicalTrials.gov number, NCT04184622.).

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Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer.

In this trial involving patients with HER2-low metastatic breast cancer, trastuzumab deruxtecan resulted in significantly longer progression-free and overall survival than the physician's choice of chemotherapy. (Funded by Daiichi Sankyo and AstraZeneca; DESTINY-Breast04 ClinicalTrials.gov number, NCT03734029.).

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Triplet Therapy, Transplantation, and Maintenance until Progression in Myeloma.

Among adults with multiple myeloma, RVD plus ASCT was associated with longer progression-free survival than RVD alone. No overall survival benefit was observed. (Funded by the National Heart, Lung, and Blood Institute and others; DETERMINATION ClinicalTrials.gov number, NCT01208662.).

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Lancet

Gun violence in the USA: children's right to health.

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Offline: WHO's erasure of Palestinians must cease.

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N Engl J Med

Audio Interview: Protecting the Immunocompromised from Covid-19.

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Chronic Traumatic Encephalopathy in the Brains of Military Personnel.

Evidence of CTE was infrequently found in a series of brains from military personnel and was usually reflected by minimal neuropathologic changes. Risk ratios for CTE were numerically higher among decedents who had contact-sports exposure and other exposures to TBI in civilian life than among those who had blast exposure or other military TBI, but the small number of CTE cases and wide confidence intervals preclude causal conclusions. (Funded by the Department of Defense-Uniformed Services University Brain Tissue Repository and Neuropathology Program and the Henry M. Jackson Foundation for the Advancement of Military Medicine.).

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Diagnosis and Treatment of Frostbite.

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Improving Treatment Approaches for Rectal Cancer.

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Liquid Biopsy for Precision Adjuvant Chemotherapy in Colon Cancer.

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Monoclonal Antibodies with Extended Half-Life to Prevent Covid-19.

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Preferential PDE4B Inhibition - A Step toward a New Treatment for Idiopathic Pulmonary Fibrosis.

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PTSD - Seeking the Ghost in the Machine.

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Shifting Tides Offer New Hope For Obesity.

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Letters&Replies

Letters to the editors and authors’ replies

Lancet

Adjustable intragastric balloon for obesity - Author's reply.

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Adjustable intragastric balloon for obesity.

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Adjustable intragastric balloon for obesity.

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Head and neck cancer: high-end technology is no guarantee of high-quality care - Authors' reply.

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Head and neck cancer: high-end technology is no guarantee of high-quality care.

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Pharmacotherapy for adults with overweight and obesity - Authors' reply.

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Pharmacotherapy for adults with overweight and obesity.

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N Engl J Med

Balanced Electrolyte Solution or Saline in the Critically Ill.

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Balanced Electrolyte Solution or Saline in the Critically Ill.

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Balanced Electrolyte Solution or Saline in the Critically Ill. Reply.

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Craving Answers.

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Craving Answers. Reply.

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Detection of Prions in a Cadaver for Anatomical Practice.

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Extracorporeal Kidney-Replacement Therapy for Acute Kidney Injury.

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Extracorporeal Kidney-Replacement Therapy for Acute Kidney Injury. Reply.

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Gene Therapy for Hemophilia A.

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Gene Therapy for Hemophilia A. Reply.

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Protection Due to Previous SARS-CoV-2 Infection.

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SARS-CoV-2 Evolution and Immune Escape in Immunocompromised Patients.

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Others

all remaining publications eg case reports, images of the month, etc…

Ann Intern Med

Annals On Call - Intravenous Iron: Rarely a Cause of Anaphylaxis.

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Summary for Patients: Cannabis-Based Products for Chronic Pain.

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Trends in Concurrent Opioid and Benzodiazepine Prescriptions in the United States, 2016 to 2019.

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Lancet

Health as activism: rethinking social medicine in India.

Pubmed   Journal   ReadQx   PMC

Implications for racial inequities in maternal health if Roe v Wade is lost.

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Incidence of perforation with intrauterine devices.

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Is the US infant formula shortage an avoidable crisis?

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Menopause care and over the counter vaginal oestradiol.

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Nigeria's new law aims to provide health insurance to all.

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Pandemic preparedness means policy makers need to work with social scientists.

Pubmed   Journal   ReadQx   PMC

Sweet's syndrome and Crohn's disease diagnosed simultaneously.

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Warnings over doctor shortages amid Italian health reforms.

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WHA sees changes to health regulations and WHO funding.

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N Engl J Med

A Black Abortion Provider's Perspective on Post-Roe America.

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Case 17-2022: A 17-Year-Old Boy with Chest Pain.

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Legg-Calvé-Perthes Disease.

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Medical Device User Fee Reauthorization - Back to Basics or Looking Ahead?

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Nineteen Days in America.

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Sclerokeratitis in Granulomatosis with Polyangiitis.

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